Rab11 family interacting protein 4 (RAB11FIP4)

Rab11 family interacting protein 4 (RAB11FIP4) is a protein that binds Rab11 GTPases via a conserved Rab11-binding domain at its C-terminus, with a key role in endocytic recycling and vesicle trafficking[3][1][6][5]. It is classified as a class II Rab11-FIP, which also features EF hands and proline-rich regions and can interact with other small GTPases such as ARF5 and ARF6[1]. RAB11FIP4 facilitates membrane delivery from recycling endosomes to the cleavage furrow during late cytokinesis and may function as an “address tag” required for successful cell abscission[3][1][6]. Pathologically, increased expression in hypoxic conditions is linked to cancer metastasis, and it is implicated in the egress of human cytomegalovirus from the nucleus[3]. RAB11FIP4 is a well-characterized effector for Rab11 proteins, integral to spatial and temporal regulation of endocytic recycling and membrane trafficking. If more detailed drug or biomarker information is needed, further specialized searches may be required; currently, RAB11FIP4 is not a direct therapeutic target of any approved drugs[3].

Other names

RAB11FIP4RAB11-FIP4

mechanistically, targeting would affect vesicle recycling and cytokinesis