RAB4B-EGLN2 readthrough long non-coding RNA (RAB4B-EGLN2)

RAB4B-EGLN2 readthrough long non-coding RNA is a naturally occurring RNA transcript resulting from read-through transcription between the neighboring RAB4B (RAB4B, member of the RAS oncogene family) and EGLN2 (egl nine homolog 2) genes on chromosome 19. This readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore unlikely to produce a protein product. As a long non-coding RNA (lncRNA), it is not known to function as a receptor, enzyme, or other classical drug target. Some studies have associated this locus or related lncRNAs with hepatocellular carcinoma, but the biological function of this specific transcript remains unclear and largely uncharacterized. There are no known drugs targeting this molecule, no defined mechanisms of action, no established biomarkers, and no reported safety concerns specifically associated with RAB4B-EGLN2[1][3][5][8].

Other names

RERT-lncRNARAB4B-EGLN2 readthroughRAB4B-EGLN2 readthrough long non-coding RNARAB4B-EGLN2 readthrough (NMD candidate)RAB4B-EGLN2 readthrough (non-protein coding)[1][5]