RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1)

RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) is a cytosolic and nucleoplasmic protein that plays a key role in the removal of damaged mitochondria via mitophagy. It does so by controlling the stability and localization of RAB7A, a small GTPase involved in late endosome/lysosome trafficking. RIMOC1 is required for the recruitment of RAB7A and ATG9A vesicles to mitochondria, and it promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy. While diseases such as Osteochondritis dissecans and Charcot-Marie-Tooth Disease are associated with this gene, there is currently no evidence that RIMOC1 serves as a direct therapeutic target, nor are there drugs targeting it specifically[1][3][5][7]. Its main classification is as a protein complex subunit involved in mitochondrial quality control.

Other names

C5orf51LOC285636UPF0600 protein C5orf51RIMOC1RAB7A-interacting MON1-CCZ1 complex subunit 1

None identified (no drugs targeting RIMOC1 directly; biological role is regulatory in mitophagy rather than direct pharmacological action)