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Rabaptin, RAB GTPase binding effector protein 1 (RABEP1)
- Target
- RABEP1
- Molecular classification
- Other (vesicle trafficking/regulator), Rabaptin protein family
01
Overview
Rabaptin, RAB GTPase binding effector protein 1 is a cytosolic effector that links Rab4/Rab5 GTPases with vesicle coat components (such as gamma-adaptin) to regulate endocytic membrane fusion, vesicle trafficking, recycling of endosomes, and protein complex trafficking through cellular compartments. It acts as a crucial mediator of early endocytosis and is implicated in diseases involving altered vesicular transport, including certain cancers and neurodegenerative disorders. The main gene encoding this protein in humans is RABEP1, and it belongs to the rabaptin protein family[1][3][5][10][11].
- Other names
- Rabaptin-5Rabaptin-4Rab GTPase-binding effector protein 1RAB5 effector proteinneurocrescinRAB5EPRABPT5RABPT5A
02
Biological functions
Vesicle-mediated transportEndocytic membrane fusionMembrane trafficking of recycling endosomesTrafficking of protein complexes (e.g., PKD1:PKD2)Protein homodimerizationProtein-protein binding
03
Disease associations
Cancer (e.g., chronic myelomonocytic leukemia)Neurodegenerative disease (e.g., multiple system atrophy)Tuberous sclerosis 2Other
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