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Target intelligence / Profile preview
Rabies Virus (RABV)
- Target
- RABV
- Molecular classification
- Virus, Lyssavirus, RNA virus
01
Overview
The rabies virus (RABV) is a neurotropic virus that causes rabies, a fatal encephalitic disease in humans and other mammals. It is most commonly transmitted through the saliva of infected animals via bites, but can also be spread if infected saliva contacts open wounds or mucous membranes. Post-exposure prophylaxis is critical as there is no cure once symptoms develop.
02
Mechanism of action
Rabies immunoglobulin provides passive immunization by neutralizing the virus. Rabies vaccine stimulates active immunity.
03
Biological functions
Viral replicationInfectionNeuroinvasionEncephalitis
04
Disease associations
RabiesEncephalitisNeurological diseaseInfection
05
Safety considerations
Risk of neurological complications from rabies infectionPotential side effects from rabies vaccine
06
Interacting drugs
Rabies immunoglobulin
1 more in the full profile.
07
Biomarkers
Viral RNA in salivaAntibodies against rabies virus
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