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Target intelligence / Profile preview
Rabies Virus Glycoprotein Epitope I (RABV-G Epitope I)
- Target
- RABV-G Epitope I
- Molecular classification
- Epitope, Viral Protein, Glycoprotein
01
Overview
Rabies virus glycoprotein epitope I refers specifically to antigenic site I within residues 226–231 on the G protein's ectodomain. This region is highly exposed, functionally essential for viral entry, and represents a dominant target recognized by most potent anti-rabies monoclonal antibodies—making it crucial both as a marker for immune response evaluation and as a focus point in modern rabies vaccine design efforts.
- Other names
- Antigenic Site I (AS I)Residues 226-231 of Rabies Virus GlycoproteinRABV-G AS I
02
Mechanism of action
Neutralizing antibodies binding to Epitope I can block viral entry by interfering with receptor binding or fusion processes.
03
Biological functions
Mediates receptor bindingFacilitates membrane fusionInduces endocytosisTarget for neutralizing antibodiesElicits protective immune responses
04
Disease associations
InfectionRabies
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