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Target intelligence / Profile preview
Rac GTPase activating protein 1 pseudogene (RACGAP1P)
- Target
- RACGAP1P
- Molecular classification
- Pseudogene, Long noncoding RNA
01
Overview
The Rac GTPase activating protein 1 pseudogene (RACGAP1P) is a non-protein-coding pseudogene homologous to the RACGAP1 gene. While pseudogenes are typically inactive remnants of protein-coding genes, RACGAP1P has been shown to function as a competing endogenous RNA (ceRNA). By acting as a molecular sponge for microRNAs such as miR-15a-5p, RACGAP1P indirectly regulates the expression of its parent gene, RACGAP1, thereby promoting the activation of oncogenic signaling pathways (Rho/ERK) in human cancers, especially hepatocellular carcinoma. Elevated expression of RACGAP1P in tumors correlates with advanced disease, poor prognosis, and early recurrence, suggesting its utility as a cancer biomarker. However, as a pseudogene, it is not considered a conventional drug target such as a receptor, enzyme, or transporter[5].
- Other names
- RACGAP1PRACGAP1 pseudogeneRac GTPase-activating protein 1 pseudogene
02
Biological functions
Competing endogenous RNA (ceRNA) function regulating the parent gene RACGAP1 via sequestration of miRNAs (notably miR-15a-5p)May modulate oncogenic signalling via indirect upregulation of RACGAP1 and activation of Rho/ERK pathways in hepatocellular carcinoma
03
Disease associations
Cancer (notably hepatocellular carcinoma, via ceRNA regulation of RACGAP1)Prognostic biomarker for poor outcome and early recurrence in liver cancer
04
Biomarkers
RACGAP1P expression has been proposed as a molecular biomarker for poor prognosis and early recurrence in hepatocellular carcinoma
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