Rac GTPase activating protein 1 pseudogene 1 (RACGAP1P1)

Rac GTPase activating protein 1 pseudogene 1 is a processed, non-coding RNA closely related in sequence to the protein-coding gene RACGAP1. While it does not encode a protein, **RACGAP1P1 is significantly upregulated in hepatocellular carcinoma tissue, especially in cases associated with early recurrence, and high expression correlates with poor prognosis**[2][3]. Mechanistically, it acts as a competing endogenous RNA (ceRNA) by “sponging” miR-15a-5p, thus preventing this microRNA from repressing its parent gene RACGAP1. This lifts the post-transcriptional inhibition on RACGAP1 and activates the pro-oncogenic RhoA/ERK signaling pathway, promoting tumor cell proliferation and migration[2][3]. There is no evidence that RACGAP1P1 interacts directly with any drugs or is directly targeted by therapeutics. It is **not a traditional drug target (receptor, enzyme, transporter, etc.)**, but rather a functional pseudogene with a notable regulatory role in cancer biology. \n\n**Summary of key points:** RACGAP1P1 is a **bona fide pseudogene** acting as a regulatory non-coding RNA, relevant as a biomarker and potential prognostic indicator in hepatocellular carcinoma, but **not a direct therapeutic target**[2][3][1][5][6]. If you are seeking information on druggable entities, the focus should be on the parent gene RACGAP1 (a GTPase-activating protein), not its pseudogene.

Other names

FKSG42RACGAP1P