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RAD51 Recombinase (Rad51)
- Target
- Rad51
- Molecular classification
- Enzyme
01
Overview
Rad51 recombinase is a highly conserved protein that plays a central role in the repair of DNA double-strand breaks (DSBs) through homologous recombination (HR). It is essential for maintaining genomic stability and preventing mutations that can lead to diseases such as cancer. Rad51 catalyzes the search for homology and strand pairing between broken DNA strands and undamaged homologous sequences, enabling accurate repair of DSBs by using an intact template. Its activity is ATP-dependent and regulated by post-translational modifications and accessory proteins.
02
Mechanism of action
Inhibition sensitizes cells to DNA-damaging agents
03
Biological functions
Homologous RecombinationDNA repairGenomic stability
04
Disease associations
CancerFanconi anemia
05
Safety considerations
Overexpression can confer resistance to apoptosis following genotoxic stress.
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