RAD52 motif containing 1 (RDM1)

RAD52 motif containing 1 (RDM1) is a multifunctional DNA repair protein that contains a motif homologous to the N-terminal region of RAD52, as well as an RNA recognition motif that is absent in RAD52[3]. RDM1 is involved in cellular responses to DNA-damaging agents, especially cisplatin. It plays a pivotal role in DNA double-strand break repair and homologous recombination by binding both single- and double-stranded DNA, especially at sites of genotoxic stress[1][3][5]. RDM1 is frequently overexpressed in several cancers (notably non-small cell lung cancer and breast, ovarian, osteosarcomas) and promotes tumor cell proliferation by supporting cell cycle transitions, suppressing apoptosis, and facilitating signaling pathways such as Raf/ERK and MEK/ERK[3]. It negatively regulates p53 and is proposed to drive oncogenesis and chemoresistance. Knockdown of RDM1 in cancer cell lines increases sensitivity to platinum-based chemotherapeutic agents and enhances apoptosis, supporting its candidacy as both a biomarker and potential therapeutic target in oncology[1][5].

Other names

RAD52 motif-containing protein 1RAD52BMGC33977RAD52 homolog BRAD52 motif 1

Increased RDM1 expression reduces sensitivity to platinum-based drugs (such as cisplatin) by promoting DNA repair; inhibition sensitizes cells to cisplatin by impeding DNA damage repair; influences cell cycle and apoptosis pathways[1][5]