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Radial spoke head 10 homolog B (RSPH10B)
- Target
- RSPH10B
- Molecular classification
- Axonemal structural protein, Motile cilia/flagella associated protein complex
01
Overview
Radial spoke head 10 homolog B (RSPH10B) is part of the radial spoke head, a multiprotein structural complex within the axoneme of motile cilia and flagella. Radial spokes connect the central pair of microtubules to peripheral doublets, transmitting regulatory signals and helping to coordinate dynein-driven motility. RSPH10B contains a MORN (Membrane Occupation and Recognition Nexus) motif and is more prominent in metazoan species, where it may specifically contribute to the third radial spoke (RS3) head formation[2][4][7]. Its protein-protein interactions help regulate the structural integrity and function of cilia/flagella and may support proper assembly and mechanical signal transduction, crucial for normal ciliary movement in tissues like the respiratory tract and reproductive system[2][3][7]. Defects in radial spoke protein complexes cause impaired ciliary motility, which underlies primary ciliary dyskinesia and other ciliopathies, though RSPH10B itself is not yet directly linked as a monogenic disease gene[5][6].
- Other names
- RSPH10BRadial spoke head 10 homolog B (Chlamydomonas)Protein R10B1_HUMAN
02
Biological functions
Regulation of ciliary and flagellar motility (mechanochemical transducer)Assembly and stability of radial spoke head complexSignal transduction within the axoneme of cilia and flagella[1][4][7]
03
Disease associations
Ciliopathies (mutations may contribute to primary ciliary dyskinesia, although direct disease associations are better established for other radial spoke proteins[5])Other: Associations with abnormal ciliary motility, which can underlie various disorders (potential, not confirmed as direct disease gene)
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