Radial spoke head 10 homolog B2 (RSPH10B2)

Radial spoke head 10 homolog B2 is a protein-coding gene encoding a structural component of the radial spoke head in eukaryotic flagella and motile cilia[1][2][3][5][6][12][14]. The radial spoke is a multi-protein complex functioning as a mechanochemical transducer between the central pair of microtubules and peripheral microtubule doublets in the 9+2 axonemal structure, regulating dynein-driven ciliary and flagellar motility[1][3][5][6][12][14]. Mutations or dysfunction in components of this complex, including RSPH10B2, can contribute to diseases such as primary ciliary dyskinesia[1]. Radial spoke head 10 homolog B2 (RSPH10B2) is a structural protein required for proper motility of cilia and flagella, associated with rare inherited diseases such as primary ciliary dyskinesia when defective, but is not currently considered a classical therapeutic target or receptor[1][2][3][5][6][12][14].

Other names

RSPH10B2radial spoke head 10 homolog B2 (Chlamydomonas)B2RC85 (UniProt)ENSG00000169402 (Ensembl)NCBI Gene 728194