Radial spoke head protein 6 homolog A (RSPH6A)

Radial spoke head protein 6 homolog A (RSPH6A) is a structural protein encoded by the RSPH6A gene in humans and is a component of the radial spoke head complex in the axoneme of eukaryotic flagella and cilia[1][2][4][5]. RSPH6A and its orthologs are essential for proper assembly and function of the sperm flagellum, where it helps regulate flagellar motility by connecting the central pair of microtubules to the outer doublets and modulating the activity of motor proteins like dynein[2][4][5][7]. RSPH6A is predominantly expressed in the testis and is essential for male fertility in mice; knockout results in short, immotile sperm[4]. Mutations or dysfunction in RSPH6A may contribute to primary ciliary dyskinesia (PCD), a disorder characterized by defective ciliary function, as well as male infertility due to abnormal sperm motility[1][2][4]. There is currently no evidence that RSPH6A is a typical therapeutic target, nor are any drugs or clinical biomarkers associated with it[2][4].

Other names

Radial spoke head-like protein 1RSHL1RSP6RSP4RSPH4Bradial spoke head protein 6 homolog Aradial spoke head-like protein 1radial spokehead-like 1