Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Radial spoke head protein 9 homolog (RSPH9)
- Target
- RSPH9
- Molecular classification
- Other, Structural ciliary protein, Axonemal protein
01
Overview
Radial spoke head protein 9 homolog (RSPH9) is a structural protein component of the radial spoke head complex found in motile cilia and flagella. It helps form the core scaffold of the radial spoke head, a mechanochemical signaling structure critical for the proper motility and waveform of cilia. The protein is essential for the assembly and maintenance of the radial spoke apparatus and for the stability of the central microtubule pair in cilia. Germline mutations in RSPH9 disrupt cilia and sperm motility, resulting in primary ciliary dyskinesia, a recessive genetic disorder characterized by impaired mucociliary clearance, chronic respiratory infections, and, in some cases, infertility and sensory defects. There are no known drugs directly targeting RSPH9, and its principal biological roles are structural and essential for organelle function rather than classical pharmacology.
- Other names
- C6orf206MRPS18AL1FLJ30845CILD12radial spoke head component 9RSPH9
02
Biological functions
Ciliary motilitySperm motilityStructural integrity of axonemes in motile ciliaAssembly of the radial spoke headCentral pair microtubule stability
03
Disease associations
Primary ciliary dyskinesiaHearing impairment (in model organisms)
04
Safety considerations
Loss-of-function variants disrupt ciliary motility, causing chronic respiratory infections, fertility problems, and possible hearing impairment
05
Biomarkers
Biallelic pathogenic variant in *RSPH9* as a diagnostic biomarker for primary ciliary dyskinesia
Beyond the preview
Go deeper on Radial spoke head protein 9 homolog (RSPH9).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Radial spoke head protein 9 homolog (RSPH9).