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Radiation-Induced Cellular Damage via Beta Emission from Yttrium-90

Molecular classification: Other

Overview

Yttrium-90 (Y-90) is a radioactive isotope used in targeted cancer therapies. It emits high-energy beta particles, which induce cellular damage primarily through ionization and free radical formation, leading to DNA damage and cell death within target tissues.

Mechanism of action

Ionizing radiation causes DNA double-strand breaks; induces apoptosis/necrosis

Biological functions

Cell deathDNA damageApoptosisNecrosis

Disease associations

Cancer

Safety considerations

Off-target radiation damageRadiation sickness

Interacting drugs

Yttrium-90 radiolabeled antibodies

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