Target intelligence / Profile preview

Radical fringe O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (RFNG)

Target: RFNG
Molecular classification: Enzyme, Glycosyltransferase

Overview

Radical fringe O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (RFNG) is an enzyme of the glycosyltransferase family that modulates Notch signaling pathways by catalyzing the addition of N-acetylglucosamine (GlcNAc) to O-fucose residues on epidermal growth factor-like repeats in Notch receptors. This post-translational modification alters Notch ligand binding and activity, affecting embryonic development and cell fate decisions. RFNG is studied for its roles in tissue patterning, cancer biology, and certain developmental diseases through its influence on Notch signaling.

Other names: Beta-1,3-N-acetylglucosaminyltransferase radical fringeRFNGO-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseradical fringe homolog

Biological functions

Regulation of Notch signalingDevelopmental processesCell fate determination

Disease associations

CancerDevelopmental disordersOther

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