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Radiolabeled autologous leukocyte (None (the process is sometimes abbreviated as "WBC scan," "In-111 leukocyte scan," or "99mTc-HMPAO leukocyte scan," but these are not abbreviations of a molecular target))

Target
None (the process is sometimes abbreviated as "WBC scan," "In-111 leukocyte scan," or "99mTc-HMPAO leukocyte scan," but these are not abbreviations of a molecular target)
Molecular classification
Other
01

Overview

Radiolabeled autologous leukocytes are a diagnostic agent made by isolating white blood cells from a patient's own blood, labeling them ex vivo with a radioactive compound (usually indium-111 or technetium-99m), and re-injecting them for imaging. After injection, these cells migrate to sites of active infection or inflammation, allowing visualization of these regions by nuclear medicine techniques such as gamma camera scintigraphy. This approach is considered the gold standard for infection imaging but is not a molecular therapy target. The procedure is regulatory-intensive, labor-intensive, and carries risks such as patient/operator exposure, but provides highly specific localization of inflammatory processes within the body

Other names
Radiolabeled leukocytelabeled autologous leukocyteindium-111-labeled leukocytetechnetium-99m HMPAO-labeled leukocyteWBC scan
02

Mechanism of action

Diagnostic imaging (cells migrate to inflammatory/infectious foci and accumulate, highlighting these sites via radionuclide imaging)

03

Biological functions

Immune response
04

Disease associations

InfectionInflammation
05

Safety considerations

Blood handling risk (pathogen exposure to operators and patients)Radiation exposure to patient and staffLimited cell viability after labeling, risk of cell aggregationFalse negatives in the immunocompromised or with reduced cell viability
06

Biomarkers

Sites of leukocyte accumulation visualized on scan are used to infer active infection or inflammation

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