Radixin (RDX)

Radixin is a cytoskeletal protein encoded by the RDX gene, fundamental for connecting the plasma membrane with actin filaments. It exerts its cellular effects primarily by regulating membrane dynamics, rigidity, and receptor localization. In the auditory system, radixin is essential for the structural integrity and signal transduction capabilities of stereocilia in hair cells; mutations in RDX cause the human deafness disorder DFNB24 and similar pathology in animal models[2][4]. Activation of radixin involves conformational changes following FERM domain binding to PIP2 and subsequent phosphorylation, enabling it to physically crosslink membranes and the actin cytoskeleton[1][2]. It is considered a molecular target in research applications, notably in studies of cell structure and auditory function, and can be experimentally inhibited with molecules such as DX-52-1[4]. No evidence of misspelling or fundamental error in the target details; radixin and the RDX gene/protein are correctly described across sources.

Other names

radixinRDXDFNB24

Inhibition (by DX-52-1): blocks radixin’s actin-membrane cross-linking, disrupting cell function especially in stereocilia