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Target intelligence / Profile preview
RAET1E Antisense RNA 1 (RAET1E-AS1)
- Target
- RAET1E-AS1
- Molecular classification
- Long non-coding RNA (lncRNA)
01
Overview
RAET1E Antisense RNA 1 (RAET1E-AS1) is a long non-coding RNA located antisense to the protein-coding RAET1E gene on chromosome 6. RAET1E-AS1 is transcribed but not translated into protein, and current functional data indicate roles in gene expression modulation and immune-related processes within tumor microenvironments. It has been found to correlate with m6A RNA modification signatures relevant for cancer prognosis and immune cell infiltration, including possible relevance for patient stratification in medulloblastoma. Additionally, it is implicated in higher-order brain connectivity changes associated with major depressive disorder, suggesting potential links to neuropsychiatric disease. However, RAET1E-AS1 is not targeted by known drugs and is not classified as a therapeutic target (such as a receptor or enzyme); it is best characterized as a non-coding regulatory RNA whose precise molecular mechanisms and disease biology remain under investigation.
- Other names
- RAET1G-AS1RAET1E-AS1
02
Biological functions
Regulation of gene expressionAssociated with immune-related functions and modulation in tumor microenvironmentMay be linked to regulation of nervous system development, ribonucleoprotein complex biogenesis, and immune cell infiltration in cancer
03
Disease associations
Cancer (especially in medulloblastoma, with m6A modification linked roles in immune regulation and prognosis)Neuropsychiatric disorders (e.g., associated with altered brain structure-function coupling in major depressive disorder)
04
Biomarkers
May serve as a biomarker for prognosis and risk stratification in particular cancers (e.g., medulloblastoma when integrated into multigene signatures)
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