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Target intelligence / Profile preview
Ral GTPase activating protein catalytic subunit alpha 2 (RALGAPA2)
- Target
- RALGAPA2
- Molecular classification
- Other (heterodimeric regulatory subunit), GTPase activator
01
Overview
RALGAPA2 encodes the catalytic subunit alpha 2 of the heterodimeric Ral GTPase Activating Protein (RalGAP) complex, which functions as a GTPase activator for Ras-like small GTPases RALA and RALB. It plays a regulatory role in the localization of exocyst components and protein localization within cells. Mutations in RALGAPA2 are associated with Ohdo syndrome (SBBYS variant), but it is not a direct therapeutic target or receptor.
- Other names
- C20orf74RGPA2
02
Biological functions
Regulation of Ral protein signal transductionRegulation of exocyst localizationRegulation of protein localization
03
Disease associations
Ohdo syndrome, SBBYS variantOther (no strong evidence for roles in major diseases like cancer, inflammation, etc.)
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