Ral GTPase-activating protein subunit alpha-1 (RALGAPA1)

Ral GTPase-activating protein subunit alpha-1 (RALGAPA1) is a catalytic subunit of the heterodimeric RalGAP1 complex, which functions as a GTPase-activating protein (GAP) for the Ras-related GTPases RALA and RALB[1][2][7]. This activity promotes GTP hydrolysis, thus inactivating these GTPases and regulating signal transduction pathways, including those involved in cell growth, differentiation, and insulin-responsive signaling[1][7]. RALGAPA1 is essential for proper neurodevelopment and has been associated with rare neurodevelopmental disorders and has a reported tumor suppressor role as part of the RalGAP complex[2]. The gene has multiple aliases and encodes an enzyme required for GTPase activation, with mutations linked to developmental and epileptic encephalopathy among other phenotypes[1][3][6][7].

Other names

GAP-related interacting protein to E12DKFZp667F074P240Ral GTPase activating protein catalytic alpha subunit 1GTPase-activating Rap/Ran-GAP domain-like 1GTPase activating RANGAP domain-like 1GAP-related-interacting partner to E12NEDHRITTULIP1GARNL1RalGAPalpha1