Ral GTPase-activating protein subunit alpha-2 (RALGAPA2)

Ral GTPase-activating protein subunit alpha-2 (RALGAPA2) is the catalytic alpha subunit of the heterodimeric RalGAP2 complex, which acts as a GTPase-activating protein for the Ras-like small GTPases RALA and RALB, thereby negatively regulating their signaling activity. The protein plays important roles in Ral protein signal transduction and the regulation of exocyst complex localization and membrane trafficking. Mutations in RALGAPA2 are associated with rare genetic disorders such as Ohdo syndrome, SBBYS variant, demonstrating its role in human development. RALGAPA2 is widely expressed in many tissues and localizes mainly to the cytosol and plasma membrane. There are currently no known drugs that directly target RALGAPA2, and it is not established as a prominent drug target in pharmacology or clinical therapy[1][3][7][9].

Other names

C20orf74KIAA1272AS250dJ1049G11.4RapGAPalpha2250 kDa substrate of Aktp220bA287B20.1dJ1049G11