Ral guanine nucleotide dissociation stimulator-like 3 (RGL3)

Ral guanine nucleotide dissociation stimulator-like 3 (RGL3) is an intracellular guanine nucleotide exchange factor (GEF) that functions primarily in *Ras protein signal transduction* and regulation of downstream pathways such as the MAPK cascade[1][3][5]. It acts as a GEF for Ral-A and as a potential effector for HRas and M-Ras, integrating signaling between Ras and Ral families[1][3][5]. RGL3 protein is mainly cytoplasmic, interacts with small GTPases Rap1, Rap2, H-Ras, N-Ras, and R-Ras (but not efficiently with Ral or Rho)[3], and modulates cell spreading, morphology, and proliferation by mediating actin polymerization through its partnership with profilin II[3]. RGL3 is expressed in multiple organs and cancers and has negative regulatory effects on Elk-1-dependent gene induction[1][3][7]. There are currently no approved drugs that specifically target RGL3, nor is it recognized as a clinical biomarker, but its role in cancer signaling suggests possible therapeutic and research interest[1][5][7].

Other names

RGL3RalGDS-like 3RalGEF-like protein 3FLJ32585Ral guanine nucleotide dissociation stimulator-like 3, mouse homolog