RalBP1-associated Eps domain-containing protein 2 (REPS2)

RalBP1-associated Eps domain-containing protein 2 (REPS2) is a protein product encoded by the REPS2 gene. It functions as part of a protein complex that regulates the endocytosis of growth factor receptors, interacting directly with a GTPase activating protein downstream of the small G protein Ral. Through these interactions, REPS2 may influence receptor internalization and growth factor signaling, as well as cell adhesion and migration via connections with ASAP1. Multiple isoforms of REPS2 exist due to alternative splicing. REPS2 is downregulated in prostate cancer progression and is associated with diseases such as Nance-Horan Syndrome and autism spectrum disorder. The protein interacts with EPN1, EPS15, RALBP1, but is not currently recognized as a direct therapeutic target, and no drugs are known to interact with it.

Other names

REPS2POB1RalBP1-associated Eps domain containing 2RalBP1-interacting protein 2Partner of RalBP1Partner of Ral-binding protein 1