Ran-binding protein 1 (RANBP1)

Ran-binding protein 1 (RANBP1) is a regulatory protein that binds to the small GTPase Ran, a key regulator of nucleocytoplasmic transport and mitotic spindle assembly[1][3]. RANBP1 modulates the activity of the Ran network by aiding RANGAP1-mediated hydrolysis of Ran-bound GTP and inhibiting RCC1-triggered guanine nucleotide exchange, thereby influencing the balance between GTP- and GDP-bound Ran[1]. This control is essential for the import and export of proteins, RNAs, and microRNAs through the nuclear pore complex, ensuring cellular compartmentalization and genome integrity[2][3]. RANBP1's expression fluctuates during the cell cycle, peaking at metaphase, and it plays a vital role in spindle checkpoint formation, chromosome segregation, and cell division[1][2]. Dysregulation or altered expression of RANBP1 is implicated in various cancers, therapy resistance (chemo-hormone, radio-resistance), neurological dysfunction, and infectious disease progression, making it a putative therapeutic target for oncology and possibly other diseases, though there are currently no direct drugs approved or in widespread clinical use targeting this protein[1][3].

Other names

Ran-binding protein 1RANBP1HTF9ARan-specific GTPase-activating proteinHpaII tiny fragments locus 9Atestis secretory sperm-binding protein Li 221n

No clinically validated drugs; generally, inhibition or modulation would affect nuclear transport, mitotic regulation, and cell proliferation