Ran-binding protein 10 (RANBP10)

Ran-binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor (GEF) that primarily acts on the small GTPase RAN, which is important for microtubule dynamics, mitotic spindle assembly, and cellular transport[1][2][3]. RANBP10 is a core component of the CTLH E3 ubiquitin-protein ligase complex, contributing to the ubiquitination and degradation of specific transcription factors, and it also functions as an adapter protein linking membrane receptors (such as the androgen receptor) to intracellular signaling pathways[1][2]. The protein interacts with β-tubulin and plays a crucial role in the formation of non-centrosomal microtubules in the cytoplasm[1][4][5]. RANBP10 is associated with cellular processes such as cell cycle regulation, spindle assembly, cytoskeletal organization, and intracellular trafficking, including nuclear import of viral genomes[2][3]. Overexpression of RANBP10 has been observed in cancers like glioblastoma and prostate cancer, contributing to cell proliferation, migration, invasion, and tumor progression, with its high expression linked to poor prognosis in some tumors[2]. While not a common therapeutic target and lacking drug interactions, RANBP10 is involved in numerous cellular signaling processes and may serve as a potential biomarker or accessory factor in tumor biology and virology[2][3].

Other names

RANBP10KIAA1464RanBP10ran-binding protein 10