Ran-binding protein 9 (RANBP9)

Ran-binding protein 9 (RANBP9) is an evolutionarily conserved scaffold and adapter protein present in both the nucleus and cytoplasm. It binds RAN (a Ras-superfamily GTPase essential for nuclear transport) and participates in diverse cellular processes, including signal transduction, DNA damage response, and cell adhesion. RANBP9 is a core member of the CTLH E3 ubiquitin-protein ligase complex, mediates protein-protein interactions, and regulates DNA repair—especially homologous recombination—by facilitating ATM kinase activation and chromatin remodeling in response to genotoxic stress. It interacts with many proteins (e.g., MET receptor, androgen receptor, CDK11, and more) and is implicated in both normal development and cancer biology. Deficiency in RANBP9 impairs DNA damage repair mechanisms, heightening cellular sensitivity to genotoxic therapies and causing profound developmental defects in model organisms.

Other names

RanBPMRanBP9BPM-LBPM90Ran-binding protein MRanBP7Ran Binding Protein in the Microtubule Organizing Centernovel centrosomal protein RanBPMran-binding protein 9centrosomal ran-binding proteinran-binding protein M

Drugs/agents may modulate RanBP9 phosphorylation (e.g., ATM inhibitors like KU-55933 affect nuclear accumulation and DDR activity). Modulation of DNA repair efficiency and sensitivity to genotoxic therapies via ATM-dependent phosphorylation and DDR regulation.