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Target intelligence / Profile preview
Ran guanine nucleotide release factor (RANGRF)
- Target
- RANGRF
- Molecular classification
- Other (Regulatory protein)
01
Overview
Ran guanine nucleotide release factor (RANGRF), also known as MOG1, is a regulatory protein that plays a critical role in promoting guanine nucleotide release from the small GTPase RAN, thereby regulating nuclear transport and mitotic spindle dynamics. RANGRF is essential for the proper cell surface expression and function of the cardiac sodium channel Na(v)1.5 (encoded by SCN5A) in cardiomyocytes and regulates membrane localization of this channel, which is crucial for normal cardiac conduction and rhythm. Mutations in RANGRF have been implicated in cardiac arrhythmias, including Brugada syndrome, by disrupting sodium channel trafficking and impairing cardiac action potential propagation[1][2][3][5][7].
- Other names
- MOG1RANGNRFHSPC165HSPC236Ran-binding protein MOG1MOG1 homolog (S. cerevisiae)MDS5
02
Biological functions
Guanine nucleotide release factor activityRegulation of intracellular trafficking of RANRegulation of cardiac sodium channel (Na(v)1.5/SCN5A) expressionRegulation of mitotic spindle dynamicsInvolvement in nuclear transport
03
Disease associations
Cardiovascular disease (notably Brugada syndrome)Other (potential roles in cardiac conduction disorders)
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