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RANBP2-like and GRIP domain-containing protein 3 (RGPD3)
- Target
- RGPD3
- Molecular classification
- Other
01
Overview
RANBP2-like and GRIP domain-containing protein 3 (RGPD3) is a protein encoded by the RGPD3 gene on human chromosome 2. It contains an N-terminal tetratricopeptide repeat (TPR) domain, two Ran-binding domains, and a C-terminal GRIP domain. The RGPD3 gene belongs to a cluster of Ran-binding protein–related genes created by primate-specific gene duplications. Its main paralog is RGPD4. Disease associations have been noted with some types of meningioma, but there is no evidence that RGPD3 itself is a therapeutic target or receptor. Its protein structure implies roles in protein-protein interaction and intracellular trafficking, but detailed functional or pharmacological characterization is lacking[4].
- Other names
- RANBP2 like and GRIP domain containing 3RGPD3RanBP2-like and GRIP domain-containing protein 3
02
Biological functions
Likely involved in intracellular traffickingProtein-protein interactionsPossibly nuclear-cytoplasmic transport
03
Disease associations
Associated with sphenoorbital meningiomaAssociated with cerebellopontine angle meningioma
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