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RANBP2-like and GRIP domain-containing protein 5 (RGPD5)
- Target
- RGPD5
- Molecular classification
- Other (Protein coding gene), Nuclear pore complex associated protein, Ran-binding domain-containing protein, GRIP domain-containing protein
01
Overview
RANBP2-like and GRIP domain-containing protein 5 is a protein encoded by the RGPD5 gene on human chromosome 2. It is highly homologous to RANBP2, a major protein of the nuclear pore complex. This protein contains Ran-binding and GRIP domains, suggesting it may be involved in protein trafficking around the nuclear envelope and in protein-protein interactions similar to its paralog RANBP2. While associated disease links include nephronophthisis and autism spectrum disorder, RGPD5 itself is not a recognized therapeutic target and is mainly studied for its basic cellular function or as a fusion partner in cancer genomics.
- Other names
- RGP5BS-63RANBP2-like and GRIP domain-containing protein 5/6Ran-Binding Protein 2-Like 1/2Sperm Membrane Protein BS-63RanBP2-Like 1/2DKFZp686I1842RanBP2L1
02
Mechanism of action
Not applicable. No known drugs target this protein.
03
Biological functions
Protein-protein interaction at the nuclear envelopeInteracts with Transportin 1May participate in nucleocytoplasmic transport, similar to RANBP2
04
Disease associations
NephronophthisisAutism Spectrum DisorderFusion events with RGPD1/other paralogs may be relevant in cancer genomics/fusion gene research
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