Rap guanine nucleotide exchange factor 5 (RAPGEF5)

Rap guanine nucleotide exchange factor 5 (RAPGEF5) is a member of the guanine nucleotide exchange factor (GEF) family that specifically functions as an activator for Rap1A, Rap2A, and MRAS/M-Ras GTPases[1][3]. It promotes the switch from inactive GDP-bound to active GTP-bound states, thereby facilitating signal transduction crucial for diverse biological processes including cell adhesion, migration, development, and the nuclear transport of β-catenin—a key effector in Wnt signaling[2][3]. RAPGEF5 is implicated in left-right patterning during embryogenesis and congenital heart disease[2][3]. It does not presently have known pharmacological antagonists or agonists but represents a potential target in cardiac, developmental, and oncogenic signaling pathways[2][3].

Other names

GFRKIAA0277MRGEFMR-GEFRepacguanine nucleotide exchange factor for Rap1M-Ras-regulated Rap GEFRelated to EpacRAPGEF5

Drugs targeting RAPGEF5 (hypothetically) would inhibit or enhance its GEF activity, modulating signal transduction by affecting GTP-bound states of Rap1A, Rap2A, MRAS (M-Ras), and β-catenin nuclear translocation[2][3].