Rap1 GTPase-activating protein 1 (RAP1GAP)

Rap1 GTPase-activating protein 1 (RAP1GAP) is an enzyme that belongs to the Ras GTPase-activating protein family and functions as a specific negative regulator of the small GTPase Rap1[2]. It accelerates the intrinsic GTPase activity of Rap1, promoting the conversion of active GTP-bound Rap1 to its inactive GDP-bound state. RAP1GAP thereby modulates diverse cellular events including cell adhesion, junction formation, and integrin function, particularly in tissues such as brain, thyroid, kidney, and platelets[2]. RAP1GAP is implicated in the regulation of platelet aggregation, influences signal transduction pathways tied to cardiovascular disease, and has been studied for its potential roles in cancer and other conditions related to cell adhesion and proliferation[2].

Other names

Rap1GAPRAP1GA1KIAA0474RAP1GAP1RAP1GAPIIRAPGAPrap1 GTPase-activating protein 1

Inhibits Rap1-mediated signal transduction by catalyzing GTP hydrolysis on Rap1, converting it to its inactive GDP-bound state[2].