Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1)

Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) is a guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP in members of the small GTPase family, particularly Rho and Ras subfamilies, including Rap1a, Rap1b, RhoA, RhoB, and KRas[8][1][3]. It stimulates the dissociation of GDP, thereby activating these G proteins to regulate diverse cellular processes such as integrin-mediated cell adhesion, cell proliferation, cytoskeletal dynamics, and various signaling networks[1][3][8]. RAP1GDS1 is implicated in cancer cell progression, mitochondrial fission, cytoskeletal remodeling, and other fundamental cellular processes[5][4]. If additional structured data (such as specific drug interactions, biomarker status, or safety profiles for therapeutic modulation) becomes available, those fields should be updated accordingly; current data do not support specific interacting drugs or clinical biomarkers at this time.

Other names

Guanine nucleotide exchange factor SmgGDSSmgGDSGDS1RAP1 GDS1

Facilitates GDP dissociation and GTP binding on target small GTPases, activating downstream signaling pathways