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Target intelligence / Profile preview
RAP2C antisense RNA 1 (RAP2C-AS1)
- Target
- RAP2C-AS1
- Molecular classification
- Other, Long non-coding RNA (lncRNA)
01
Overview
RAP2C antisense RNA 1 (RAP2C-AS1) is a long non-coding RNA (lncRNA) located antisense to the RAP2C gene. RAP2C-AS1 does not encode a protein but exerts biological functions through the regulation of gene expression. It has been identified as being downregulated in clear cell renal cell carcinoma and bladder cancer and is associated with improved patient outcomes when expressed at higher levels. RAP2C-AS1 modulates tumor cell proliferation and migration and is implicated in the regulation of the tumor microenvironment, partly through influencing the expression of immune checkpoint molecules such as CD274 and CTLA4. Its expression correlates with clinical parameters of tumor progression, and it shows potential as a prognostic biomarker in cancer, but is not a direct therapeutic target, receptor, enzyme, or transporter[1][3][4].
- Other names
- RAP2C-AS1
02
Biological functions
Regulation of gene expressionRegulation of cell proliferationRegulation of cell migration
03
Disease associations
CancerPrognostic biomarker in clear cell renal cell carcinoma (ccRCC)Prognostic biomarker in bladder cancer
04
Biomarkers
Prognostic biomarker for survival in ccRCCPotential biomarker for prognosis and drug response in bladder cancer
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