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Target intelligence / Profile preview
Retinoic Acid-Related Orphan Receptor Alpha (RORα)
- Target
- RORα
- Molecular classification
- Nuclear hormone receptor, Transcription factor
01
Overview
RORα is a member of the nuclear hormone receptor superfamily and functions as a ligand-dependent transcription factor. It binds to ROR response elements (ROREs) and regulates gene expression involved in development, immune regulation, metabolism, and circadian rhythm.
- Other names
- RAR-related orphan receptor alphaNR1F1
02
Mechanism of action
Transcriptional activator by recruiting coactivators upon binding to target gene promoters. Competes with REV-ERB family members.
03
Biological functions
Neural developmentCerebellar developmentImmune regulationLipid metabolismCircadian rhythm regulationCellular differentiation
04
Disease associations
Intellectual developmental disorderEpilepsyCerebellar ataxiaRobinow syndromeCancer progressionAutoimmune diseasesMetabolic disorders
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