RARA antisense RNA 1 (RARA-AS1)

RARA antisense RNA 1 (RARA-AS1) is a long non-coding antisense RNA with elevated expression in various human cancers, most notably glioblastoma, and plays key roles in regulating cell proliferation, invasion, and migration[2][4][7]. Functional studies demonstrate that knockdown of RARA-AS1 reduces tumor cell proliferation and migration, highlighting its significance in tumor progression. RARA-AS1 is highly correlated with immune checkpoint markers, mismatch repair genes, and participates in oncogenic and immune-related pathways. It is considered both a potential therapeutic target and prognostic biomarker, particularly in glioblastoma and other malignancies[2][4][7]. No direct drug is currently known to interact with RARA-AS1, but it is a subject for further drug discovery efforts, including RNA-based therapies[2].

Other names

CTD-2267D19.2RARA-AS1

RARA-AS1's mechanism involves RNA binding protein interaction (e.g., CSTF2T-mediated axis). It regulates oncogenic pathways such as cell cycle, P53 pathway, nucleotide metabolism, estrogen signaling, and ubiquitin-mediated proteolysis. Furthermore, it modulates immune checkpoint genes and has potential as a target for antisense RNA therapeutics through oligonucleotide-mediated knockdown.