Ras and Rab interactor 2 (RIN2)

Ras and Rab interactor 2 (RIN2) is a Ras effector and guanine nucleotide exchange factor (GEF) for Rab5, a small GTPase involved in endocytic pathway regulation[6][1]. RIN2 functions as a molecular adaptor, coupling Ras and Rab5 signaling to promote endothelial cell adhesion, endocytosis, and early endosome trafficking[1][6]. RIN2 contains a Ras-associating domain (RA), a RIN-homology (RH) domain, a VPS9 GEF domain for Rab5, and an SH2 domain for protein interactions[1]. Loss-of-function mutations in RIN2 cause MACS syndrome, a rare elastic tissue disorder characterized by macrocephaly, alopecia, cutis laxa, and scoliosis[3]. RIN2 is broadly expressed in human tissues and plays a role in cell adhesion, migration, and vascular morphogenesis, particularly through modulating integrin endocytosis and Rac1 activation[1][6]. There are currently no known drugs targeting RIN2 directly as a therapeutic mechanism.

Other names

Ras and Rab interactor 2RIN2RAB5 interacting protein 2ras and Rab interactor 2RAS association (RalGDS/AF-6) domain containing protein JC265RAS inhibitor JC265RAS interaction/interference protein 2MACS