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Target intelligence / Profile preview
Ras-associating and dilute domain-containing protein (RADIL)
- Target
- RADIL
- Molecular classification
- Other (protein-coding gene), Cytoskeletal signaling effector (interacts with small GTPases, not an enzyme or receptor)
01
Overview
Ras-associating and dilute domain-containing protein (RADIL) is a cytoplasmic protein encoded by the *RADIL* gene on human chromosome 7p22.1. RADIL acts as a downstream effector of Rap GTPases, playing an essential role in regulating cell adhesion, migration, and the movement of neural crest precursor cells during development. It is involved in intracellular signaling processes—particularly those governing cytoskeletal changes and substrate-dependent cell spreading. RADIL is located in microtubules and interacts with other proteins to mediate cell adhesion and migration. There are no current drugs, biomarkers, or safety considerations attached to RADIL in clinical or preclinical therapeutics.
- Other names
- RADILRap associating with DIL domainKIAA1849FLJ10324RASIP2ras-associating and dilute domain-containing proteinRap GTPase interactorRas association and DIL domains
02
Mechanism of action
Not applicable; no drugs directly target RADIL
03
Biological functions
Cell adhesionMigration of neural crest precursorsSubstrate adhesion-dependent cell spreadingNeutrophil adhesion and motility
04
Disease associations
Cancer (potential role in cell migration and invasion, although not a major cancer target)Enterobiasis (listed as associated, but relevance unclear)Other (developmental processes, neural crest cell migration)
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