Ras association domain-containing protein 7 (RASSF7)

Ras association domain-containing protein 7 (RASSF7) is a member of the N-terminal Ras association domain family, distinct from classical RASSF proteins, and acts as a centrosome-associated protein essential for mitotic spindle formation and progression through mitosis[1][2][3][4]. RASSF7 is widely expressed in embryonic and adult tissues, localizes to the centrosome in a microtubule-dependent manner, and is a key regulator of microtubule growth and dynamics during cell division[1][2][4]. Knockdown or loss of RASSF7 disrupts spindle formation, leads to mitotic arrest, nuclear breakdown, apoptosis, and defects in chromosomal congression; it has been implicated in the maintenance of genomic stability, with dysregulation observed in certain cancers[1][2][3][4]. Key points from recent studies: - **Role in mitosis:** RASSF7 is required for proper spindle formation and mitotic progression; its depletion leads to mitotic arrest, failed division, and aneuploidy[1][2][3][4]. - **Microtubule regulation:** It directly affects centrosome function and microtubule regrowth, influencing the structural integrity of the mitotic spindle[4]. - **Cancer association:** RASSF7 is upregulated in a variety of cancer types, and aberrant expression may promote or be associated with oncogenic processes[4]. - **Mechanistic detail:** Its functional significance centers on its interaction with microtubules and involucration in centrosome- and cytoskeleton-dependent mitotic events; its deficiency impairs Aurora B activation and chromosomal alignment[4]. No current drugs or drug mechanisms are established for RASSF7, and it is not a recognized therapeutic target at this time.

Other names

C11orf13HRC1HRAS1FAP88CFAP88HRAS1-related cluster protein 1ras association domain-containing protein 7HRAS1-related cluster-1Ras association (RalGDS/AF-6) domain family (N-terminal) member 7Ras association (RalGDS/AF-6) domain family 7