Ras association domain family member 1 (RASSF1)

Ras association domain family member 1 (RASSF1) is a tumor suppressor protein that acts as a molecular scaffold and is involved in regulation of cell cycle arrest, apoptosis, microtubule stabilization, and inhibition of tumorigenesis[1][2][3][4]. The RASSF1 gene produces multiple isoforms, with RASSF1A and RASSF1C being the most abundant in normal tissues. RASSF1A binds to and stabilizes microtubules, suppresses cyclin D1 and cyclin A2 accumulation, and promotes cell cycle arrest and apoptosis, in part through modulation of the Hippo pathway and through interactions with Ras GTPases[1][2][4]. Loss of RASSF1A function, commonly via promoter hypermethylation, is strongly associated with the pathogenesis of many cancers, highlighting its role as a frequent tumor suppressor inactivation event in oncogenesis[1][3][6]. RASSF1A interacts with multiple signaling and structural proteins—including Ras, microtubule-associated proteins, death receptors, and Hippo pathway kinases—coordinating responses to DNA damage, mitogenic stimuli, and pro-apoptotic signals[2][4]. It is widely studied as a biomarker for cancer diagnosis and prognosis, especially through detection of its promoter methylation status[1][6]. There are currently no approved drugs directly targeting RASSF1, but epigenetic therapy to restore its function is an area of research.

Other names

Ras association domain-containing protein 1RDA32NORE2AREH3P21123F2RASSF1ARas association (RalGDS/AF-6) domain family member 1