Ras association domain family member 10 (RASSF10)

Ras association domain family member 10 (RASSF10) is a member of the N-terminal RASSF proteins that acts as a tumor suppressor. It is frequently epigenetically silenced in various cancers, including leukemia, hepatocellular carcinoma, glioma, and gastric cancer, primarily via promoter hypermethylation. RASSF10 plays major roles in suppressing cell proliferation, inducing apoptosis, and regulating mitosis; its molecular function includes inhibition of the Cdk1–cyclin-B complex (with NPM dependency), and modulation of p53 and Wnt/β-catenin signaling pathways. Methylation status of its promoter is a prognostic biomarker for cancer and its re-expression may provide therapeutic benefits. The designation \"RASSF10 divergent transcript\" is non-standard and likely refers to transcript variants of RASSF10, but the protein product is typically 507 amino acids, encoded by a single exon gene on chromosome 11p15.2[1][2][3][4][5].\n\nNote: \"RASSF10-DT\" is not a standard drug target, and users should reference the canonical target \"Ras association domain family member 10 (RASSF10)\" for structured annotation.

Other names

RASSF10LOC644943Ras association domain family member 10

Restoration of RASSF10 expression via promoter demethylation suppresses tumor growth and induces apoptosis\n RASSF10 modulates the Cdk1–cyclin-B kinase complex, induces mitotic arrest, and activates/or inhibits signaling pathways (p53, Wnt/β-catenin)