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Ras GTPase (Ras)
- Target
- Ras
- Molecular classification
- Small GTPase, GTP-binding protein, Signaling protein
01
Overview
Ras GTPases are small, single-subunit guanosine-nucleotide-binding proteins that function as molecular switches in the cell. They cycle between an inactive GDP-bound state and an active GTP-bound state, regulating a wide array of cytoplasmic signaling pathways involved in gene expression, cell growth, survival, differentiation, and apoptosis. Mutations in RAS genes, especially those that impair intrinsic or GAP-stimulated GTP hydrolysis, lead to constitutive activation, acting as oncogenic drivers found in approximately 10–20% of human cancers.
- Other names
- HRASKRASNRASK-RasH-RasN-Ras
02
Mechanism of action
Inhibition of Ras GTPase activity or downstream signaling pathways
03
Biological functions
Signal transductionCell growthCell survivalCell differentiationApoptosisCell proliferationMechanobiological processes
04
Disease associations
CancerDevelopmental disorders (Noonan syndrome, Costello syndrome, cardiofaciocutaneous syndrome)
05
Safety considerations
Drug resistanceOff-target effectsLimited efficacy in certain cancer subtypes
06
Interacting drugs
Sotorasib
2 more in the full profile.
07
Biomarkers
KRAS mutation status (e.g., G12C, G12D)NRAS mutation statusHRAS mutation status
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