Ras homolog family member C (RhoC)

Ras homolog family member C (RhoC) is a small GTPase enzyme (~21 kDa), and a member of the Rho family of GTP-binding proteins that regulate actin cytoskeleton organization, cell motility, and cell shape[1][6]. RhoC cycles between active GTP-bound and inactive GDP-bound states, functioning as a molecular switch in signal transduction[1][3][4]. It is mainly localized to the cytoplasm and plasma membrane, where it regulates the assembly of focal adhesions, actin stress fibers, and cell contractility[6]. RhoC is essential for cell directional migration and speed, modulating cell motility during normal processes and in cancer metastasis[1]. Overexpression or aberrant activation of RhoC has been implicated in various cancers, driving tumor cell invasion, metastasis, and angiogenesis[1][3][2]. It participates in cancer-related signal pathways suchs as MAPK, PI3K/AKT, and Notch, as well as cytoskeletal effectors (IQGAP1, ROCK-1, MMP9, FMNL3)[1]. RhoC is considered a promising cancer biomarker and therapeutic target, with RNA interference and vaccine-based therapies currently under investigation[1].

Other names

H9ARH9ARHCRHOH9rho-related GTP-binding protein RhoC

Inhibition of GTPase signaling, suppression of cell proliferation, inhibition of metastasis, and inhibition of cytoskeletal rearrangement.