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Target intelligence / Profile preview
Ras homolog family member H (RhoH)
- Target
- RhoH
- Molecular classification
- GTPase, Small G protein, Ras superfamily, Rac subfamily
01
Overview
Ras homolog family member H (RhoH) is a small GTPase of the Ras superfamily, expressed specifically in hematopoietic cells where it functions as a negative regulator of cell growth and survival[1][3][7]. RhoH lacks intrinsic GTPase activity and remains constitutively active, acting as an antagonist of Rac signaling in hematopoietic lineages[3]. In T lymphocytes, it plays a critical adaptor role in T-cell receptor (TCR) signaling and is required for proper thymocyte development and immune function. Chromosomal translocations involving RHOH are associated with non-Hodgkin's lymphoma and its deregulation/mutation is implicated in leukemia, lymphoma, and immunodeficiency syndromes[1][2][3][7].
- Other names
- RhoHARHHTTFras homolog gene family, member Hras homolog family member H
02
Biological functions
Negative regulator of cell growth and survivalModulator of T-cell receptor signalingRegulator of thymocyte developmentRegulator of migration and differentiation of hematopoietic cells
03
Disease associations
Cancer (particularly leukemia, lymphoma, non-Hodgkin's lymphoma)Immunodeficiency (inherited mutations leading to T-cell deficiency)Autoimmune and inflammatory diseases (psoriatic arthritis candidate association)
04
Safety considerations
Deregulation and hypermutation linked to hematological malignanciesCentral role in immune signaling may present challenge for therapeutic targeting
05
Biomarkers
Mutations in RHOH for immunodeficiency diagnosisChromosomal translocations involving RHOH in lymphoma
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