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Ras homolog gene family member A

Molecular classification: Small GTPase

Overview

Ras homolog gene family member A (RHOA) is a small GTPase protein belonging to the Rho family of GTPases. It is a molecular switch that cycles between an inactive GDP-bound state and an active GTP-bound state, playing a central role in regulating various cellular processes, including actin cytoskeleton dynamics, cell cycle progression, and transcriptional regulation. Aberrant RHOA activity is implicated in cancer and other diseases.

Biological functions

Actin organizationCell shape/polarity/locomotionTranscriptional regulationCell cycle controlSignal transduction

Disease associations

Cancer progression/metastasisGenetic syndromes

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