Ras-like protein family member 11B (RASL11B)

Ras-like protein family member 11B (RASL11B) is a small cytosolic GTPase belonging to the Ras superfamily. Unlike many Ras-related proteins, RASL11B lacks typical prenylation signals and is predominantly localized in the cytoplasm rather than at membranes. It is ubiquitously expressed, with highest levels in placenta and macrophages, and is implicated in multiple biological processes, including the negative regulation of cell proliferation and migration, promotion of cell cycle arrest and apoptosis, and chondrogenic differentiation of stem cells. Functionally, RASL11B acts as a modulator of the TGF-β signaling pathway and is involved in developmental, inflammatory, and vascular pathophysiologies. Pathologically, RASL11B is downregulated in clear cell renal cell carcinoma (suggesting tumor-suppressive properties), upregulated in neuroblastoma (as a putative biomarker), and identified as a key factor in chondrogenic differentiation (possible target for cartilage repair). Its precise molecular interactors and mechanisms of action in human disease are the subject of ongoing research[1][2][3][5].

Other names

RAS like family 11 member BRASL11BRas-like protein family member 11BRSLBB_HUMANHGNC:23804NCBI Gene:65997