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RAS-MAPK Pathway
- Target
- RAS-MAPK Pathway
- Molecular classification
- Signal transduction pathway
01
Overview
The RAS-MAPK pathway is a highly conserved signal transduction cascade that relays extracellular signals from cell surface receptors to the nucleus, regulating key cellular processes such as proliferation, differentiation, survival, and gene expression. Dysregulation of this pathway is implicated in many cancers and other diseases, making it a major focus for cancer therapy development.
- Other names
- Ras-Raf-MEK-ERK pathway
02
Mechanism of action
Varies depending on the specific drug and target within the pathway (e.g., inhibition of kinase activity).
03
Biological functions
Cell cycle progressionCellular proliferationDifferentiationSurvival/apoptosisMotilityAngiogenesisGene expression
04
Disease associations
CancerDevelopmental syndromes (RASopathies)
05
Safety considerations
Resistance developmentOff-target effectsParadoxical activation of the pathway in certain contextsDevelopment of secondary malignancies
06
Interacting drugs
MEK inhibitors
2 more in the full profile.
07
Biomarkers
RAS mutationsBRAF mutationsERK phosphorylation levels
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