Target intelligence / Profile preview

RAS Protein (RAS)

Target: RAS
Molecular classification: Small GTPase, Ras superfamily

Overview

RAS proteins are small GTPases that act as binary molecular switches, cycling between an active (GTP-bound) and inactive (GDP-bound) state. They play a central role in transmitting signals from cell surface receptors to intracellular signaling pathways, thereby regulating key cellular processes such as proliferation, differentiation, apoptosis, cytoskeletal organization, adhesion, and migration. Mutations in RAS genes, especially KRAS, are among the most common oncogenic events in human cancers, leading to uncontrolled cell growth and tumorigenesis.

Other names: KRASHRASNRAS

Mechanism of action

Inhibition of RAS activity or downstream signaling pathways.

Biological functions

Signal transductionCell proliferationCell differentiationApoptosisCytoskeletal organizationCell adhesionCell migration

Disease associations

Cancer

Safety considerations

Pathway complexity and redundancy limiting therapeutic successResistance to therapies targeting downstream kinases

Interacting drugs

Farnesyltransferase inhibitors

2 more in the full profile.

Biomarkers

KRAS mutations (codons 12, 13, 61)

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