Ras protein activator like 1 (RASAL1)

Ras protein activator like 1 (RASAL1) is a member of the GAP1 family of GTPase-activating proteins that suppress RAS function by enhancing the intrinsic GTPase activity of RAS proteins, thus converting active RAS-GTP to the inactive RAS-GDP form. This crucial regulation prevents excessive cell proliferation and maintains normal cellular signaling. RASAL1 is highly expressed in endocrine tissues and is implicated in the negative regulation of the Ras-ERK/MAPK pathway. Loss or dysfunction of RASAL1 has been associated with increased Ras pathway activity and contributes to the development of various cancers and proliferative disorders.

Other names

RasGAP-activating-like protein 1RASAL1GAP1 family protein

For theoretical inhibitors: Inhibition or modulation of RASAL1 would affect Ras deactivation and downstream MAPK/ERK signaling. RASAL1 itself inactivates RAS by accelerating GTP hydrolysis, converting active RAS-GTP to inactive RAS-GDP.