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RAS Protein Family (RAS)

Target: RAS
Molecular classification: Small GTPase, Enzyme, GTPase

Overview

The RAS protein family comprises highly conserved small monomeric enzymes acting as pivotal regulators ("molecular switches") within eukaryotic cells. Their ability to toggle between active/inactive states underlies their central role in transmitting extracellular growth signals into precise cellular responses. Dysregulation through mutation leads directly to cancer or developmental disease phenotypes due to aberrant control over fundamental processes like proliferation and differentiation.

Other names: HRASKRASNRASRas GTPases

Mechanism of action

Inhibition of RAS activity

Biological functions

Signal transductionCell proliferationCell differentiationCell survivalApoptosisRegulation of cell growth

Disease associations

CancerRASopathiesDevelopmental disordersOncogenesis

Safety considerations

Drug resistanceOff-target effectsLimited efficacy in some RAS-driven cancers

Biomarkers

KRAS mutation statusNRAS mutation statusHRAS mutation status

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